ABSTRACT
Background: The alpha wave of COVID-19 brought death and dismay to patients and to providers respectively. Remdesivir nor plasma was available. We studied this cohort to evaluate the need for mechanical ventilation (MV) and Renal replacement therapy and the outcome of hospital discharge. Is well known that the covid-19 causes Cytokine Release Syndrome (CRS), therefore, producing dysregulation and an increase in the immune response, interleukine 6, plays and central role in triggering the (CRS) and stimulating other inflammatory markers. Method(s): A retrospective-observational study. We reviewed the patients admitted to the intensive care unit of a metropolitan hospital in the Los Angeles area from February 17th, 2020, till March 14th, 2020. There was 24 patient who was in the ICU. At the time, Remdesivir was not available at the hospital Results: Eight of the 24 patients received Kevzara. Of the 8 patients, 2 required RRT while of the 16 patients who did not receive Kevzara, 6 required RRT. All 8 patients who received RRT also had MV for varying number of days and all were alive at 28 days. Among the 16 patients who did not receive Kevzara, 11 required mechanical ventilation, and 6 got RRT. 5 patients got both MV and RRT. The number of days of RRT was required was 12 in the Kevzara group and 4.25 in the none-Kevzara group. Chi Square value of 5.3706 p value = <0.5 Conclusion(s): Kevzara reduced 28-d mortality in the alpha wave of covid-19. There is incremental value in the use of Kevzara and Organ support technologies such as MV and RRT in the ICU. As the patient's life is prolonged in critical care units, there is increased demand for renal replacement therapy resources.